Description

Spdp-Peg8-Acid is a heterobifunctional, amine- and sulfhydryl-reactive crosslinking reagent featuring a long, hydrophilic polyethylene glycol (PEG) spacer. This compound is engineered to facilitate the conjugation of biomolecules, such as proteins and peptides, while significantly improving solubility and reducing aggregation. It is an essential tool for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay formulation.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a critical component for constructing stable, cleavable linkages between cytotoxic payloads and monoclonal antibodies.
• Protein/Peptide Labeling: Used for site-specific modification of cysteine residues with fluorescent dyes, enzymes, or other reporter molecules.
• Surface Immobilization: Enables the oriented coupling of proteins or antibodies onto biosensor chips, microarrays, and other solid supports.
• Polymer-Protein Conjugation: Facilitates PEGylation strategies to enhance the pharmacokinetic properties and stability of therapeutic proteins.
• Diagnostic Reagent Development: Employed in the synthesis of enzyme-linked or fluorescently-labeled detection probes for immunoassays.
• Biomaterial Functionalization: Used to introduce bioactive ligands onto hydrogels and other polymeric materials for tissue engineering applications.

Basic Information

Product Name	Spdp-Peg8-Acid
CAS No.	1334177-96-6
Molecular Formula	C37H66N2O16S2
Molecular Weight	858.1 g/mol
Synonyms	SPDP-PEG8-acid; NHS-PEG8-SPDP; 3-(2-Pyridyldithio)propionyl-PEG8-acid; Succinimidyl 3-((2-(3-(3-(2-(3-(2-(2-(3-(2,5-Dioxopyrrolidin-1-yl)oxy)-2-oxoethoxy)ethoxy)propanoyloxy)ethoxy)ethoxy)propanamido)ethoxy)ethoxy)ethyl) 3-(2-pyridyldithio)propanoate; SPDP-PEG8-COOH; SPDP-PEG8-COOH; SPDP-PEG8-NHS ester (precursor form)
EINECS	Contact for details

Quality Control

Our Spdp-Peg8-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere after opening and to allow the vial to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by functional group titration)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, moderately soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.