Description

Cbz-n-Amido-Peg8-Acid CAS NO 1334177-87-5 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a carboxybenzyl (Cbz) protected amine and a terminal carboxylic acid group. This bifunctional linker is engineered to provide controlled conjugation and enhanced solubility in bioconjugation and pharmaceutical research applications. It is primarily utilized by researchers and manufacturers in the fields of proteomics, drug discovery, and advanced material science for creating PEGylated therapeutics, diagnostic agents, and sophisticated cross-linking systems.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional cross-linker for coupling peptides, proteins, or other biomolecules via its amine-reactive and carboxyl-reactive ends.
• PEGylation Reagent: Used to introduce a hydrophilic PEG spacer to drugs, proteins, or nanoparticles, improving solubility, stability, and circulation time.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a building block or a soluble polymer-supported reagent for the synthesis of complex peptide-PEG conjugates.
• Prodrug Development: Facilitates the design of cleavable prodrugs where the Cbz group allows for specific enzymatic or chemical release of the active compound.
• Diagnostic Agent Formulation: Employed in the development of contrast agents and imaging probes to enhance biocompatibility and targeting.
• Hydrogel and Biomaterial Fabrication: Incorporated as a functional monomer to create smart, responsive hydrogels with tailored degradation profiles.
• Antibody-Drug Conjugate (ADC) Research: Provides a stable, hydrophilic linker system for connecting cytotoxic payloads to monoclonal antibodies.

Basic Information

Product Name	Cbz-n-Amido-Peg8-Acid
CAS No.	1334177-87-5
Molecular Formula	C31H51N3O13
Molecular Weight	673.75 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-3,6,9,12,15,18,21,24-octaoxahexacosan-26-amide-1-carboxylic Acid; Fmoc-N-amido-PEG8-acid; Carboxybenzyl-PEG8-acid; Z-NH-PEG8-COOH; N-Cbz-8-amino-3,6,9,12,15,18,21,24-octaoxahexacosanoic Acid; Benzyl N-(26-carboxy-3,6,9,12,15,18,21,24-octaoxahexacosyl)carbamate; Cbz-NH-PEG8-CH2CH2COOH; PEG8 Cbz Amido Acid
EINECS	Contact for details

Quality Control

Every batch of Cbz-n-Amido-Peg8-Acid is manufactured under strict quality management protocols. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your GMP, ISO, or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.