Description

Bis-Peg5-Pfp Ester CAS NO 1334177-78-4 is a specialized heterobifunctional polyethylene glycol (PEG) crosslinker featuring pentafluorophenyl (PFP) ester reactive groups. This compound is engineered for efficient and selective bioconjugation, enabling the stable coupling of biomolecules under mild aqueous conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, where precise and reliable linker chemistry is critical.

Application

• Bioconjugation and Protein Modification: Used to crosslink peptides, proteins, and antibodies with other biomolecules or solid surfaces for drug delivery systems and diagnostic assays.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component for attaching cytotoxic payloads to monoclonal antibodies.
• PEGylation Chemistry: Facilitates the site-specific PEGylation of therapeutic proteins to enhance solubility, stability, and circulation half-life.
• Hydrogel and Biomaterial Synthesis: Acts as a crosslinking agent in the creation of biocompatible hydrogels for tissue engineering and controlled release applications.
• Surface Functionalization: Used to modify nanoparticles, chips, and other substrates with bioactive ligands for biosensing and lab-on-a-chip technologies.
• Chemical Biology Probes: Enables the synthesis of activity-based probes and affinity labels for studying enzyme function and protein interactions.

Basic Information

Product Name	Bis-Peg5-Pfp Ester
CAS No.	1334177-78-4
Molecular Formula	C34H42F10O14
Molecular Weight	852.69 g/mol
Synonyms	Bis-PEG5-PFP ester; 1,11-Bis(2,5-dioxopyrrolidin-1-yl)-3,6,9-trioxaundecane-1,11-dioate (PFP ester analog); PEG-based PFP diester; α,ω-Bis(pentafluorophenyl) PEG5 ester; Heterobifunctional PEG-PFP crosslinker; PFP-PEG5-PFP; Pentafluorophenyl ester of PEG5 diacid; NHS-PEG5-PFP (common functional analog)
EINECS	Contact for details

Quality Control

Every batch of Bis-Peg5-Pfp Ester is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (HPLC), identity (NMR, MS), and functional group integrity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.