Description

Lipoamido-Dpeg(R)12-Acid CAS NO 1334172-71-2 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a lipoamide moiety and a terminal carboxylic acid group. This unique bifunctional structure makes it a critical building block for creating advanced bioconjugates and drug delivery systems, offering controlled hydrophilicity and a reactive site for further chemical modification. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precision linkers for developing targeted therapeutics, diagnostic agents, and functional biomaterials.

Application

• Pharmaceutical Linker: A key intermediate for synthesizing antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted biotherapeutics.
• PEGylation Reagent: Used to modify proteins, peptides, and nanoparticles to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Polymer Chemistry: Serves as a functional monomer or macromonomer for synthesizing novel biodegradable and stimuli-responsive copolymers.
• Surface Functionalization: Employed to introduce reactive carboxyl groups onto material surfaces for subsequent biomolecule immobilization in biosensor and diagnostic device development.
• Cross-linking Agent: Utilized in hydrogel formation and biomaterial fabrication due to its ability to form amide bonds with amine-containing compounds.
• Lipid Nanoparticle (LNP) Component: Can be incorporated into lipid formulations to modulate surface properties and targeting capabilities for nucleic acid delivery.

Basic Information

Item	Detail
Product Name	Lipoamido-Dpeg(R)12-Acid
CAS No.	1334172-71-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	α-Lipoic acid-PEG12-acid; Lipoic Acid-PEG12-COOH; Dithiolane-PEG12-acid; 5-(1,2-Dithiolan-3-yl)pentanoic acid-PEG12-acetic acid; Lipoyl-PEG12-acid; Thioctic acid-PEG12-carboxylic acid; Lipoamide-PEG12-acid; LA-PEG12-COOH
EINECS	Contact for details

Quality Control

Our Lipoamido-Dpeg(R)12-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.