Description

Amino-Peg8-T-Boc-Hydrazide is a heterobifunctional polyethylene glycol (PEG) derivative featuring a Boc-protected hydrazide group and a primary amine, separated by a flexible 8-unit PEG spacer. This compound is a critical building block in bioconjugation and linker chemistry, enabling the controlled attachment of biomolecules, drugs, or probes under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing advanced therapeutics and analytical tools.

Application

• Bioconjugation Linker: Used to create stable linkages between proteins, antibodies, peptides, and other biomolecules with drugs, fluorophores, or solid supports.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key component in constructing cleavable or non-cleavable linkers for targeted cancer therapies.
• PEGylation Reagent: Employed to introduce a hydrophilic PEG chain onto molecules to improve solubility, stability, and pharmacokinetic profiles.
• Crosslinking Agent: Facilitates the formation of hydrogels, polymer networks, and surface modifications for biomaterial engineering.
• Diagnostic Probe Synthesis: Used in the preparation of labeled probes for imaging, biosensing, and immunoassay applications.
• Drug Delivery Systems: Incorporated into nanocarriers and micelles to enable pH-sensitive or enzymatically triggered drug release.

Basic Information

Product Name	Amino-Peg8-T-Boc-Hydrazide
CAS No.	1334169-96-8
Molecular Formula	C31H63N3O12
Molecular Weight	669.85 g/mol
Synonyms	Boc-NH-PEG8-NHNH2; Boc-Amino-PEG8-Hydrazide; tert-Butyl (2-(2-(2-(2-(2-(2-(2-(2-(2-Hydrazinyl-2-oxoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate; 2,5,8,11,14,17,20,23-Octaoxa-26-azaheptacosan-27-oic acid, 26-[(1,1-dimethylethoxy)carbonyl]-, hydrazide; Amino-PEG8-Boc-Hydrazide; Boc-Hydrazide-PEG8-Amine; Heterobifunctional PEG8 linker, Boc-hydrazide/amine
EINECS	Contact for details

Quality Control

Our Amino-Peg8-T-Boc-Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.