Description

Mpeg8-Nh-Mal CAS NO 1334169-90-2 is a heterobifunctional polyethylene glycol (PEG) derivative, featuring a maleimide group on one end and an amine group on the other, connected by an 8-unit PEG spacer. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise, site-specific linkage of biomolecules such as peptides, proteins, and antibodies. It is essential for researchers and manufacturers in the fields of biopharmaceuticals, advanced drug delivery systems, and diagnostic assay development who require high-purity, functional linkers.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via thiol-maleimide chemistry.
• PEGylation Reagent: Modification of therapeutic proteins and peptides to enhance solubility, stability, and circulation half-life.
• Diagnostic Probe Synthesis: Construction of fluorescent or enzyme-labeled probes for immunoassays and imaging.
• Surface Functionalization: Immobilization of biomolecules onto nanoparticles, biosensors, or chromatography matrices.
• Crosslinking Agent: For creating defined protein-protein or protein-polymer conjugates.
• Polymer Therapeutics: Synthesis of advanced, multi-functional polymeric drug carriers.

Basic Information

Product Name	Mpeg8-Nh-Mal
CAS No.	1334169-90-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8-Arm PEG-Maleimide; Maleimide-PEG8-amine; α-Maleimide-ω-amine octaethylene glycol; MAL-PEG8-NH2; Heterobifunctional PEG 8, maleimide-amine; PEG8 spacer, maleimide and amine terminated; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl] pentanedioate
EINECS	Contact for details

Quality Control

Every batch of Mpeg8-Nh-Mal is produced and tested under strict quality management protocols to ensure it meets the high-purity standards required for sensitive bioconjugation applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and functional group integrity. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Maleimide)	≥ 90%
Functional Group Assay (Amine)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.