Description

Tirofiban-D9 Hydrochloride is a high-purity, deuterated isotopologue of the antiplatelet agent Tirofiban, specifically designed for use as an internal standard in quantitative bioanalytical methods. This compound is critical for ensuring the accuracy and reliability of pharmacokinetic and pharmacodynamic studies, particularly in drug development and clinical research. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers requiring precise and interference-free quantification of Tirofiban in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard (SIL-IS) in LC-MS/MS and HPLC methods for the precise quantification of Tirofiban in plasma, serum, and other biological fluids.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles, bioavailability, and metabolism in preclinical and clinical trials.
• Method Development and Validation: Used as a critical reference material to develop, optimize, and validate robust analytical assays in compliance with GLP and FDA/EMA guidelines.
• Drug Metabolism Studies: Facilitates the investigation of Tirofiban's metabolic pathways and the identification of its metabolites.
• Quality Control in Manufacturing: Can be utilized in impurity profiling and assay verification of Tirofiban active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Tirofiban-D9 Hydrochloride
CAS No.	1331911-68-2
Molecular Formula	C22H27D9N2O5S • HCl
Molecular Weight	495.15 g/mol (approx.)
Synonyms	N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine-D9 Hydrochloride; L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride, deuterated; Tirofiban (d9) hydrochloride; Tirofiban Internal Standard; Tirofiban-d9 HCl; MK-383-d9; Aggrastat-d9 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Tirofiban-D9 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to confirm deuterium incorporation and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and other critical specifications to support your regulatory submissions and quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.