Description

n-Acetyl-S-(2,5-Dimethylbenzene)-L-Cysteine-D3 is a deuterium-labeled analog of a key cysteine metabolite, designed for use as an internal standard in advanced analytical techniques. This compound is critical for ensuring the accuracy and reliability of quantitative bioanalytical measurements, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by research institutions, pharmaceutical developers, and contract research organizations (CROs) engaged in drug metabolism and biomarker research.

Application

• Internal Standard for LC-MS/MS: Essential for precise quantification of the corresponding non-deuterated metabolite in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to track the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Biomarker Research and Validation: Supports the accurate measurement of cysteine-derived metabolites as potential disease biomarkers.
• Stable Isotope Dilution Assays: Enables highly accurate and sensitive assays by correcting for sample preparation losses and instrument variability.
• Toxicology and Environmental Monitoring: Facilitates the study of exposure to specific xenobiotics and their metabolic pathways.

Basic Information

Product Name	n-Acetyl-S-(2,5-Dimethylbenzene)-L-Cysteine-D3
CAS No.	1331909-07-9
Molecular Formula	C₁₃H₁₄D₃NO₃S
Molecular Weight	~ 268.36 g/mol
Synonyms	N-Acetyl-S-(2,5-dimethylphenyl)-L-cysteine-d3; N-Acetyl-3-(2,5-dimethylphenylthio)alanine-d3; Acetylcysteine D3 derivative; Deuterated N-Acetyl-S-(2,5-dimethylbenzyl)-L-cysteine; Internal Standard for 2,5-Dimethylphenylmercapturic acid-d3; 2,5-Dimethylphenyl mercapturate-d3; N-Acetyl-S-(2,5-xylyl)-L-cysteine-d3; Stable Isotope Labeled Cysteine Metabolite
EINECS	Contact for details

Quality Control

This high-purity reference material is produced under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive analytical applications. Each lot is characterized using NMR, LC-MS, and HPLC to confirm isotopic purity, chemical purity, and identity. A comprehensive Certificate of Analysis (COA) detailing the isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.