Description

Thiouric Acid-13C3 Sodium Salt Dihydrate is a stable isotope-labeled derivative of thiouric acid, where three carbon atoms are replaced with the 13C isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and diagnostic developers working on metabolic studies, pharmacokinetics, and biomarker validation.

Application

• Quantitative Mass Spectrometry (LC-MS/MS): Serves as a critical internal standard for the precise quantification of thiouric acid and related metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the metabolic pathways and clearance rates of purine-based pharmaceuticals.
• Clinical Diagnostics: Enables accurate measurement of thiouric acid levels in patient samples for research into conditions like hyperuricemia and gout.
• Biomarker Research: Provides a stable isotope reference for developing and validating assays targeting purine metabolism biomarkers.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities in drug substances.
• Regulatory Submissions: Supports bioanalytical method development and validation data packages required for FDA and EMA filings.

Basic Information

Product Name	Thiouric Acid-13C3 Sodium Salt Dihydrate
CAS No.	1330823-16-9
Molecular Formula	C13C3H3N4NaO3S • 2H2O
Molecular Weight	Contact for details
Synonyms	6-Thioxo-1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurine-13C3 Sodium Salt Dihydrate; 1,3-Dimethyl-2,6-dioxo-6-thioxo-1,2,3,6-tetrahydropurine-13C3 Sodium Salt Dihydrate; Sodium 1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purine-8-thiolate-13C3 Dihydrate; 13C3-Labeled Thiouric Acid Sodium Salt; [13C3]-Thiouric Acid Sodium Salt Dihydrate; TMU-13C3 Sodium Salt Dihydrate
EINECS	Contact for details

Quality Control

Every batch of Thiouric Acid-13C3 Sodium Salt Dihydrate is manufactured under strict quality systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for stable isotope-labeled reference materials. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as isotopic purity, chemical purity, and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥99 atom % 13C
Isotopic Enrichment	≥99% on three labeled positions
Water Content (KF)	8.0 - 12.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.