Description

n-Benzyl n-Demethyl Trimebutine-D5 is a deuterated analog of a key pharmaceutical intermediate, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based assays, particularly in pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug development and bioanalysis.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Trimebutine and related metabolites.
• Critical component in bioanalytical method development and validation for clinical and preclinical studies.
• Supporting pharmacokinetic (PK) and pharmacodynamic (PD) research to understand drug absorption, distribution, metabolism, and excretion (ADME).
• Enabling drug metabolism studies to identify and quantify deuterium isotope effects.
• Used in quality control laboratories for the analysis of active pharmaceutical ingredients (APIs) and finished drug products.
• Application in forensic and anti-doping analysis for precise substance identification and quantification.

Basic Information

Product Name	n-Benzyl n-Demethyl Trimebutine-D5
CAS No.	1330189-05-3
Molecular Formula	C24H30D5NO3
Molecular Weight	~389.6 g/mol
Synonyms	Trimebutine-d5 (N-Benzyl, N-Demethyl); 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate-d5 (N-Benzyl, N-Demethyl); Deuterated Trimebutine Internal Standard; 3,4,5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester-d5; MB-530B-d5; Polibutin-d5 (deuterated analog); TRMB-d5; CAS 1330189-05-3
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality control to ensure isotopic purity and chemical integrity, which are critical for accurate analytical results. Each batch is characterized using advanced techniques including NMR (for deuterium incorporation) and High-Resolution Mass Spectrometry (HRMS). A comprehensive Certificate of Analysis (COA) is provided, detailing assay purity (typically ≥98% by HPLC), isotopic enrichment (≥99 atom % D), and chromatographic profile. We support compliance with GMP/GLP guidelines for use in regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. For long-term stability, store desiccated at -20°C. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 99 atom % D
Chemical Purity (Titration/NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.