Description

Dl-Threo-Ritalinic Acid-D10 (Major) is a deuterated analog of the primary metabolite of methylphenidate, a widely used central nervous system stimulant. This high-purity, isotopically labeled compound is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods. It serves as an essential internal standard in mass spectrometry for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors, enabling precise pharmacokinetic studies and drug monitoring.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of methylphenidate and its metabolites in biological matrices.
• Pharmacokinetic and Metabolism Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• Forensic Toxicology: Used in confirmatory testing and quantification of methylphenidate (Ritalin®) in forensic casework and workplace drug testing programs.
• Pharmaceutical Quality Control: Supports method development and validation for the assay of active pharmaceutical ingredients and related substances.
• Reference Material for Certified Standards: Serves as a key component in the preparation of certified reference materials (CRMs) for regulatory compliance.
• Doping Control Analysis: Applied in sports anti-doping laboratories for the precise detection of stimulant drugs.

Basic Information

Product Name	Dl-Threo-Ritalinic Acid-D10 (Major)
CAS No.	1330180-60-3
Molecular Formula	C14H9D10NO2
Molecular Weight	235.34 g/mol (approximate)
Synonyms	DL-threo-Methylphenidate Acid-D10; α-Phenyl-2-piperidineacetic Acid-D10, Methyl Ester; Ritalinic Acid-d10; Methylphenidate Metabolite-d10; 2-Piperidineacetic Acid, α-phenyl-, Methyl Ester-d10; (±)-three-Methylphenidate Acid-d10; DL-Methylphenidate Acid-d10; Contact for IUPAC name.
EINECS	Contact for details

Quality Control

Every batch of Dl-Threo-Ritalinic Acid-D10 (Major) is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of significant unlabeled species.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D10)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.