Description

Rac-Vigabatrin-13C,D2 (Major) is a high-purity, isotopically labeled analog of the pharmaceutical compound Vigabatrin, specifically designed for advanced analytical and research applications. This compound is essential for use as an internal standard in quantitative mass spectrometry, enabling precise and accurate measurement of Vigabatrin levels in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism, pharmacokinetic (PK/ADME) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Critical for the quantitative bioanalysis of Vigabatrin in plasma, serum, and other biological fluids, ensuring data integrity and regulatory compliance.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Vigabatrin.
• Biomedical Research: Serves as a stable isotope-labeled tracer in mechanistic studies related to GABA transaminase inhibition and neurological research.
• Pharmaceutical Quality Control: Supports method development and validation for the assay and impurity profiling of Vigabatrin in active pharmaceutical ingredients (APIs) and finished drug products.
• Clinical Research: Enables precise therapeutic drug monitoring (TDM) in clinical trials to correlate drug exposure with efficacy and safety outcomes.

Basic Information

Product Name	Rac-Vigabatrin-13C,D2 (Major)
CAS No.	1330171-61-3
Molecular Formula	C613CH9D2NO2
Molecular Weight	132.16 g/mol (approximate)
Synonyms	(±)-4-Amino-5-(13C)hex-5-enoic-5,5-d2 acid; (RS)-Vigabatrin-13C,d2; γ-Vinyl-GABA-13C,d2; Racemic Vigabatrin labeled with carbon-13 and deuterium; GVG-13C,d2; Sabril-13C,d2 (labeled analog); 4-Aminohex-5-enoic-13C,d2 acid
EINECS	Contact for details

Quality Control

Every batch of Rac-Vigabatrin-13C,D2 (Major) is manufactured and analyzed under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on isotopic enrichment, chemical purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.