Description

Dehydro Nisoldipine-D7 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise measurement of its parent compound, nisoldipine.

Application

• Primary use as an internal standard for the accurate quantification of nisoldipine via LC-MS/MS and GC-MS.
• Critical component in pharmacokinetic studies and drug metabolism research (DMPK) to track drug concentration in biological matrices.
• Enables high-accuracy bioanalytical method development and validation for regulatory submissions.
• Used in clinical research and therapeutic drug monitoring (TDM) protocols.
• Supports impurity profiling and stability-indicating assay development for pharmaceutical quality control.
• Facilitates deuterium-labeling studies in mechanistic organic chemistry and metabolic pathway elucidation.

Basic Information

Product Name	Dehydro Nisoldipine-D7
CAS No.	1329836-20-5
Molecular Formula	C20H17D7N2O6
Molecular Weight	391.45 g/mol
Synonyms	Deutero Nisoldipine-D7; Nisoldipine-d7 (Dehydro); 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester-d7; Bay k 5552-d7; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester, deuterated; Isradipine analogue-d7; Internal Standard for Nisoldipine Quantification
EINECS	Contact for details

Quality Control

Every batch of Dehydro Nisoldipine-D7 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and analytical results. Our quality standards are designed to meet the rigorous demands of GLP and GMP-compliant research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.