Description

o-Desmethyl Mebeverine Acid-D5 is a deuterated internal standard of the primary metabolite of the antispasmodic drug mebeverine. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in drug development and regulatory compliance.

Application

• Primary use as a deuterated internal standard for the precise quantification of o-desmethyl mebeverine acid in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for mebeverine hydrochloride formulations.
• Enabling accurate metabolite profiling and drug metabolism studies during preclinical and clinical development phases.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing validated analytical data.
• Quality control and method validation in forensic and clinical toxicology laboratories.
• Used in stable isotope dilution analysis to correct for analyte loss during sample preparation and matrix effects.

Basic Information

Product Name	o-Desmethyl Mebeverine Acid-D5
CAS No.	1329488-46-1
Molecular Formula	C22H22D5NO4
Molecular Weight	Contact for details
Synonyms	4-[Ethyl[2-(4-methoxyphenyl)-1-methylethyl]amino]butyric-3,3,4,4,4-d5 Acid; Mebeverine Acid-d5 Metabolite; 4-[Ethyl[2-(4-methoxyphenyl)-1-methylethyl]amino]butyric-d5 Acid; Desmethyl Mebeverine Acid-d5; o-Desmethyl Mebeverine-d5 Acid; Mebeverine Metabolite D5; Deuterated Mebeverine Acid Internal Standard
EINECS	Contact for details

Quality Control

Every batch of o-Desmethyl Mebeverine Acid-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and chromatographic data is provided with each shipment to ensure traceability and compliance with your method validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.