Description

1-Biotinylamino-3,6,9-Trioxaundecane-11-Ol is a specialized biotin derivative featuring a hydrophilic polyethylene glycol (PEG) spacer arm, designed to enhance solubility and reduce steric hindrance in conjugation chemistry. This compound is engineered to facilitate the efficient and stable biotinylation of biomolecules, a critical step in numerous detection and purification workflows. It is an essential reagent for researchers and manufacturers in the fields of diagnostics, proteomics, and biopharmaceutical development, where reliable and high-affinity binding is paramount.

Application

• Bioconjugation Reagent: Primary use for labeling antibodies, proteins, peptides, and nucleic acids with biotin for subsequent detection with streptavidin/avidin systems.
• Diagnostic Assay Development: Key component in the manufacturing of ELISA, lateral flow assays, and other immunoassay platforms requiring robust signal amplification.
• Affinity Purification Systems: Used to functionalize resins and surfaces for the capture and purification of target biomolecules.
• Cell Surface Labeling: For tagging membrane proteins in flow cytometry (FACS) and microscopy applications.
• Drug Delivery & Targeting: As a linker in the development of biotinylated drug conjugates and targeted therapeutic agents.
• Microarray and Biosensor Fabrication: For immobilizing biomolecules on chip surfaces in a controlled and oriented manner.
• Life Science Research: A versatile tool in molecular biology, biochemistry, and cell biology research for pull-down assays and protein interaction studies.

Basic Information

Product Name	1-Biotinylamino-3,6,9-Trioxaundecane-11-Ol
CAS No.	1322625-82-0
Molecular Formula	C19H35N3O6S
Molecular Weight	433.57 g/mol
Synonyms	Biotin-PEG3-OH; Biotin-PEG3-alcohol; Biotinylated triethylene glycol; 11-Hydroxy-3,6,9-trioxa-2-azaundecan-1-aminium, 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-, inner salt; Biotin-amido-PEG3-alcohol; Biotin-PEG3-OH; N-Biotinyl-3,6,9-trioxaundecane-1,11-diamine derivative; Biotin-PEG3 linker
EINECS	Contact for details

Quality Control

Our 1-Biotinylamino-3,6,9-Trioxaundecane-11-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and structural confirmation via NMR and mass spectrometry, to ensure high batch-to-batch consistency and performance reliability. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.