Description

Biotinylamidoethyl-Dithiomethylenemalonic Acid Bis(4-Aminobutyric Acid) is a sophisticated, high-purity biochemical building block designed for advanced research and development. This compound is critical for applications requiring precise bioconjugation and targeted molecular delivery, offering a unique combination of biotin affinity and cleavable disulfide functionality. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and biotech companies working on next-generation therapeutics, targeted drug delivery systems, and sensitive assay platforms.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, and peptides with biotin tags for detection and purification.
• Targeted Drug Delivery Systems: As a key linker component in antibody-drug conjugates (ADCs) and other targeted therapeutics, leveraging its cleavable disulfide bond for controlled payload release.
• Diagnostic Assay Development: In the fabrication of advanced ELISA, lateral flow assays, and other immunoassays requiring high-affinity capture and signal amplification.
• Affinity Chromatography: For the synthesis of specialized resins used in the purification of biomolecules via streptavidin-biotin interaction.
• Cell Surface Engineering: For modifying cell membranes with targeting ligands in cell therapy and imaging applications.
• Proteomics Research: As a tool for labeling, isolating, and studying protein complexes and interactions.
• Nanoparticle Functionalization: To attach targeting moieties to liposomes, polymeric nanoparticles, and other nanocarriers.

Basic Information

Product Name	Biotinylamidoethyl-Dithiomethylenemalonic Acid Bis(4-Aminobutyric Acid)
CAS No.	1322625-02-4
Molecular Formula	C24H41N5O8S2
Molecular Weight	591.73 g/mol
Synonyms	Biotin-SS-4-Aminobutyric Acid; Biotin-SS-GABA; Biotinylated Disulfide Linker; Biotin-PEG2-SS-GABA; 5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[[2-[2-[4-[(4-aminobutanoyl)amino]butanoylamino]ethyl]disulfanyl]acetyl]amino]ethyl]pentanamide; Biotin-AAEE-SS-GABA-GABA; Biotin-SS-AEEA-GABA-GABA; N-Biotinyl-2-aminoethyl disulfide di(4-aminobutyric acid)
EINECS	Contact for details

Quality Control

Our Biotinylamidoethyl-Dithiomethylenemalonic Acid Bis(4-Aminobutyric Acid) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and functional testing. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Under these conditions, the product is stable for at least 24 months. The compound is hygroscopic (moisture-sensitive) and the disulfide bond may be susceptible to reduction under certain conditions; handle under an inert atmosphere when appropriate for the application.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Functional Activity	Biotin binding capacity confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.