Description

R-Pralatrexate is a high-purity, non-racemic stereoisomer of the antimetabolite chemotherapeutic agent Pralatrexate. This compound is of significant interest for pharmaceutical research and development, particularly in the synthesis of targeted cancer therapeutics. It serves as a critical intermediate or reference standard for researchers and manufacturers in the oncology and medicinal chemistry sectors.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of the active pharmaceutical ingredient (API) Pralatrexate.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) of Pralatrexate drug substances and products.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the development of novel folate analog inhibitors.
• Oncology Drug Development: Supports preclinical and clinical research programs focused on targeted therapies for T-cell lymphomas and other cancers.
• Process Chemistry: Utilized in the optimization and scale-up of stereoselective synthesis routes for complex pharmaceutical molecules.

Basic Information

Product Name	R-Pralatrexate
CAS No.	1320211-70-8
Molecular Formula	C₂₃H₂₃N₇O₅
Molecular Weight	477.48 g/mol
Synonyms	(R)-Pralatrexate; (R)-10-Propargyl-10-deazaaminopterin; (2R)-2-[[4-[(1R)-1-[(2,4-Diaminopteridin-6-yl)methyl]but-3-yn-1-yl]benzoyl]amino]pentanedioic acid; (R)-10-Propargyl-10-deazaaminopterin; R-Isomer of Pralatrexate; PDX R-Enantiomer; NSC-754230 (R-form)
EINECS	Contact for details

Quality Control

Our R-Pralatrexate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-Isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.