Description

S-Pralatrexate is a high-purity, enantiomerically pure form of the antifolate agent Pralatrexate, specifically designed for advanced pharmaceutical research and development. This compound is critical for investigating targeted therapeutic strategies, particularly in oncology, due to its potent inhibition of dihydrofolate reductase. It is an essential reference standard and active pharmaceutical ingredient (API) intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation cancer treatments.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control in API manufacturing.
• Oncology Research: Serves as a key intermediate or active moiety in the R&D of novel chemotherapeutic agents targeting lymphomas and other cancers.
• Mechanistic Studies: Employed in biochemical and pharmacological studies to understand folate metabolism inhibition and drug resistance mechanisms.
• Preclinical Development: Utilized in formulation studies, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and toxicology assessments for new drug candidates.
• Process Chemistry: Acts as a critical building block or intermediate in the synthetic pathway for producing targeted therapeutic molecules under GMP conditions.

Basic Information

Product Name	S-Pralatrexate
CAS No.	1320211-69-5
Molecular Formula	C₂₃H₂₃N₇O₅
Molecular Weight	477.48 g/mol
Synonyms	(S)-Pralatrexate; (2S)-2-[[4-[(1,2-Dihydro-2-oxo-3H-1,3-benzimidazol-1-yl)methyl]benzoyl]amino]pentanedioic acid; (S)-10-Propargyl-10-deazaaminopterin; PDX (S-enantiomer); S-10-Propargyl-10-deazaaminopterin; Folotyn (S-enantiomer); (S)-CB3717 analog
EINECS	Contact for details

Quality Control

Our S-Pralatrexate is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chiral purity, chemical assay, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity qualification, making it suitable for research and development use under quality frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.