Description

Gal Beta(1-3)[Neu5Ac Alpha(2-6)]Galnac-α-Pnp is a sophisticated synthetic oligosaccharide derivative, specifically a p-nitrophenyl (PNP) glycoside of a sialylated core 1 O-glycan structure. This compound serves as a critical enzymatic substrate and research tool for the study of glycosyltransferases, glycosidases, and other carbohydrate-active enzymes involved in glycobiology. It is essential for researchers and developers in the fields of glycobiology research, diagnostic assay development, and pharmaceutical discovery, particularly for investigating cancer biomarkers, immune cell interactions, and infectious disease mechanisms.

Application

• Enzymatic Substrate for Glycosyltransferases/Glycosidases: Used in high-throughput screening (HTS) assays to study enzyme kinetics, inhibition, and specificity for sialyltransferases and other enzymes modifying O-glycans.
• Glycobiology Research: A vital tool for probing the biosynthesis, structure, and function of sialylated O-linked glycoproteins, which are crucial in cell signaling and recognition.
• Diagnostic Reagent Development: Employed in the development of enzymatic assays for detecting specific glycosidase activities relevant to certain disease states or microbial infections.
• Pharmaceutical & Biologics R&D: Supports drug discovery efforts targeting carbohydrate-protein interactions, including the development of inhibitors for cancer metastasis and inflammatory diseases.
• Biochemical Standard: Serves as a purified reference standard for the calibration of analytical instruments (HPLC, MS) and the validation of experimental protocols in glycoscience.
• Synthetic Glycan Array Construction: Used as a building block or probe for creating glycan arrays to study protein-carbohydrate binding profiles.

Basic Information

Product Name	Gal Beta(1-3)[Neu5Ac Alpha(2-6)]Galnac-α-Pnp
CAS No.	1316822-90-8
Molecular Formula	C31H44N2O20
Molecular Weight	764.69 g/mol
Synonyms	α-PNP-6'-sialyl-T antigen; PNP-6'-Sialyl-T Antigen; 6'-Sialyl-T Antigen α-p-Nitrophenyl Glycoside; Galβ1-3(Neu5Acα2-6)GalNAcα-PNP; Sialyl Core 1 O-Glycan PNP Derivative; Neu5Acα2-6Galβ1-3GalNAcα-PNP; p-Nitrophenyl 6'-O-(N-acetyl-α-neuraminyl)-β-D-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-α-D-galactopyranoside
EINECS	Contact for details

Quality Control

Our high-purity biochemicals are produced and handled under strict quality management protocols. Each batch of Gal Beta(1-3)[Neu5Ac Alpha(2-6)]Galnac-α-Pnp undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity, purity, and structural integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes batch-specific data. Our quality commitment ensures the material meets the exacting standards required for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.