Description

Mpeg8-Nhs CAS NO 1316189-13-5 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring an amine-reactive N-hydroxysuccinimide (NHS) ester group. This compound is critical for creating stable, biocompatible conjugates by covalently linking to primary amines on proteins, peptides, and other biomolecules. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require reliable, well-defined PEGylation reagents to enhance solubility, reduce immunogenicity, and prolong circulation time of therapeutic agents.

Application

• Protein and Antibody PEGylation: Conjugation to lysine residues for therapeutic protein modification to improve pharmacokinetics and stability.
• Peptide Drug Conjugation: Attachment to peptide-based pharmaceuticals to enhance bioavailability and in vivo half-life.
• Nanoparticle and Liposome Functionalization: Surface modification of drug delivery carriers to impart stealth properties and enable targeted ligand attachment.
• Diagnostic Reagent Preparation: Labeling of antibodies, enzymes, or other proteins with fluorescent dyes or other detection moieties for assay development.
• Biomaterial Surface Engineering: Creating non-fouling, biocompatible coatings on medical devices and implants.
• Crosslinking Agent: Used in the synthesis of hydrogels or polymer networks for controlled release applications.
• Linker for Solid-Phase Synthesis: Facilitating the attachment of molecules to amine-functionalized resins or surfaces.

Basic Information

Product Name	Mpeg8-Nhs
CAS No.	1316189-13-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8-Arm PEG NHS Ester; Octa-Arm Poly(ethylene glycol) N-Hydroxysuccinimide Ester; Octafunctional PEG-Succinimidyl Glutarate; mPEG8-NHS Ester; PEG8-NHS; Multi-arm PEG NHS; Star-shaped PEG NHS Ester; Poly(ethylene glycol) octa(succinimidyl glutarate)
EINECS	Contact for details

Quality Control

Our Mpeg8-Nhs is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and functional group analysis, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis of the active NHS ester.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Complies
Purity (HPLC)	≥ 95%
Functional Substitution	> 90%
Molecular Weight (Average)	As per order specification
Moisture Content (KF)	< 1.0%
Solubility	Soluble in DMF, DMSO, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.