Description

Bis-Peg3-Pfp Ester is a specialized heterobifunctional crosslinker featuring two pentafluorophenyl (PFP) ester groups connected by a triethylene glycol (PEG3) spacer. This compound is engineered for efficient and selective bioconjugation, primarily serving as a critical reagent in the synthesis of antibody-drug conjugates (ADCs) and other advanced biopharmaceuticals. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require high-purity, reliable linkers for constructing stable, functional biomolecular architectures.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: A key building block for creating stable, cleavable, or non-cleavable linkers between monoclonal antibodies and potent cytotoxic payloads.
• Protein and Peptide Modification: Used for site-specific labeling, PEGylation, or immobilization of biomolecules onto solid supports or other proteins.
• Biomaterial and Hydrogel Fabrication: Serves as a crosslinking agent in the development of functionalized polymers and biocompatible scaffolds for tissue engineering.
• Diagnostic Reagent Development: Employed in the conjugation of detection molecules (e.g., fluorophores, enzymes) to antibodies or oligonucleotides for assay kits.
• Small Molecule Prodrug Activation: Facilitates the creation of prodrugs where the active agent is released upon specific biological triggers.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions, cellular pathways, and drug delivery mechanisms through controlled conjugation.

Basic Information

Product Name	Bis-Peg3-Pfp Ester
CAS No.	1314378-13-6
Molecular Formula	C₂₄H₂₂F₁₀O₈
Molecular Weight	628.42 g/mol
Synonyms	1,11-Bis(2,5-dioxo-1-pyrrolidinyloxycarbonyloxy)-3,6,9-trioxaundecane; PEG3 Bis PFP Ester; Bis(PEG3) PFP Ester; 3,6,9-Trioxaundecanedioic acid bis(2,3,4,5,6-pentafluorophenyl) ester; PFP-PEG3-PFP; 1,11-Bis(pentafluorophenoxycarbonyloxy)-3,6,9-trioxaundecane; Bis-PEG3-pentafluorophenyl ester; Heterobifunctional PEG crosslinker (PFP-PEG3-PFP)
EINECS	Contact for details

Quality Control

Our Bis-Peg3-Pfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.