Description

Bis-Peg4-Pfp Ester CAS NO 1314378-12-5 is a high-purity, heterobifunctional polyethylene glycol (PEG) crosslinker featuring pentafluorophenyl (PFP) ester reactive groups. This compound is critical for creating stable, site-specific conjugations in aqueous environments, offering superior reactivity and selectivity over traditional NHS esters. It is an essential building block for researchers and manufacturers in the bioconjugation and pharmaceutical development sectors who require reliable, high-yield coupling agents for peptides, proteins, and other biomolecules.

Application

• Bioconjugation Reagent: For the efficient, site-specific crosslinking of amines in peptides, proteins, and antibodies under mild aqueous conditions.
• ADC (Antibody-Drug Conjugate) Development: Used as a key linker component to attach cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapies.
• PEGylation Chemistry: Serves as a functionalized PEG spacer to modify biomolecules, improving solubility, stability, and pharmacokinetic properties.
• Hydrogel Formation: Acts as a crosslinking agent in the synthesis of biocompatible PEG-based hydrogels for drug delivery and tissue engineering.
• Surface Functionalization: Employed to create reactive surfaces on nanoparticles, biosensors, and diagnostic devices for subsequent biomolecule immobilization.
• Polymer Chemistry: Utilized in the synthesis of functionalized polymers and dendrimers with precise architecture for advanced material science applications.

Basic Information

Product Name	Bis-Peg4-Pfp Ester
CAS No.	1314378-12-5
Molecular Formula	C30H32F10O12
Molecular Weight	750.56 g/mol
Synonyms	1,11-Bis(2,5-dioxo-1-pyrrolidinyloxy)-3,6,9-trioxaundecane; Bis-NHS-PEG4; Bis(succinimidyl) PEG4; Bis-PEG4-NHS ester; PEG4 bis-PFP ester; α,ω-Bis-pentafluorophenyl PEG4 ester; 3,6,9,12-Tetraoxatetradecanedioic acid bis(2,3,4,5,6-pentafluorophenyl) ester; 1,11-Bis(2,5-dioxopyrrolidin-1-yl)-3,6,9-trioxaundecane-1,11-dionate
EINECS	Contact for details

Quality Control

Our Bis-Peg4-Pfp Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.