Description

Lipoamido-Peg4-Acid CAS NO 1314378-10-3 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a lipoamide group and a terminal carboxylic acid. This compound is engineered to serve as a critical linker and spacer molecule in bioconjugation and pharmaceutical development, enabling the stable attachment of bioactive molecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, advanced drug delivery systems, and diagnostic probe development.

Application

• Bioconjugation Reagent: For coupling peptides, proteins, or antibodies to surfaces, nanoparticles, or other biomolecules via its carboxylic acid terminus.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a functionalized PEG spacer to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• PEGylation Agent: Used to modify therapeutic proteins or peptides to enhance stability, reduce immunogenicity, and prolong circulation half-life.
• Crosslinking and Immobilization: Facilitates the covalent immobilization of enzymes or other proteins onto solid supports for biosensor and diagnostic assay development.
• Liposome and Nanoparticle Functionalization: Enables the surface modification of drug delivery carriers for targeted therapy applications.
• Biomaterial Modification: Incorporates functional groups into hydrogels or polymer scaffolds for tissue engineering and regenerative medicine.
• Research Grade Chemical: Used in academic and industrial R&D for exploring novel drug delivery pathways and biochemical tools.

Basic Information

Product Name	Lipoamido-Peg4-Acid
CAS No.	1314378-10-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,2-Dithiolane-3-pentanamide, 5-[1-oxo-2,5,8,11-tetraoxatetradec-14-yl]-; Lipoic acid-PEG4-acid; α-Lipoic acid-PEG4-propionic acid; 5-(1-Oxo-2,5,8,11-tetraoxatetradec-14-yl)-1,2-dithiolane-3-pentanamide; Lipoamide-PEG4-COOH; Thioctic acid-PEG4-acid; PEG4-Lipoamide-acid; Heterobifunctional PEG Lipoamide Acid
EINECS	Contact for details

Quality Control

Our Lipoamido-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.