Description

Ng,Ng-Dimethylarginine-D6 Dihydrochloride is a high-purity, stable isotope-labeled analog of asymmetric dimethylarginine (ADMA), a key endogenous inhibitor of nitric oxide synthase. This compound is essential for precise quantitative analysis in biomedical research, providing unmatched accuracy as an internal standard in mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, clinical diagnostic developers, and academic institutions conducting advanced metabolomic and cardiovascular disease studies.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the accurate quantification of endogenous ADMA and related metabolites in biological matrices like plasma, serum, and urine.
• Biomarker Research: Enables precise studies on the role of ADMA in cardiovascular diseases, renal dysfunction, and endothelial function.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in stable isotope dilution assays to study the pharmacokinetics of arginine-related drug candidates.
• Clinical Diagnostic Assay Development: Serves as a reference standard in the development and validation of high-sensitivity diagnostic kits for cardiovascular risk assessment.
• Metabolomics and Proteomics: Facilitates targeted metabolite profiling in systems biology research to understand metabolic pathways.
• Quality Control Reference Material: Acts as a certified reference material for ensuring the accuracy and reproducibility of analytical methods in contract research organizations (CROs).

Basic Information

Product Name	Ng,Ng-Dimethylarginine-D6 Dihydrochloride
CAS No.	1313730-20-9
Molecular Formula	C8H12D6Cl2N4O2
Molecular Weight	279.22 g/mol
Synonyms	ADMA-d6 Dihydrochloride; Asymmetric Dimethylarginine-d6 Dihydrochloride; N(G),N(G)-Dimethyl-L-arginine-d6 Dihydrochloride; L-NG,NG-Dimethylarginine-d6 Dihydrochloride; (2S)-2-Amino-5-[(amino-dimethyl-d6-amino)imino]pentanoic acid Dihydrochloride; (S)-2-Amino-5-((amino(dimethyl-d6)amino)imino)pentanoic acid Dihydrochloride; Isotope Labeled ADMA Dihydrochloride; Nitric Oxide Synthase Inhibitor-d6
EINECS	Contact for details

Quality Control

Every batch of Ng,Ng-Dimethylarginine-D6 Dihydrochloride is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.