Description

1-Isothiocyanato-Peg3-Azide is a heterobifunctional crosslinker featuring both an isothiocyanate (NCS) and an azide (N3) group, connected by a triethylene glycol (PEG3) spacer. This molecular architecture is critical for creating stable, site-specific conjugates between amine-containing biomolecules and alkyne-modified targets via click chemistry. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced materials science, enabling the precise construction of drug delivery systems, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides.
• Click Chemistry Reagent: Acts as a versatile linker for copper-catalyzed (CuAAC) or strain-promoted (SPAAC) azide-alkyne cycloaddition reactions.
• Surface Functionalization: Modification of nanoparticles, biosensors, or solid supports with amine-reactive groups for subsequent bio-immobilization.
• Polymer and Dendrimer Synthesis: Building block for creating functionalized polymers with tailored biological activity or material properties.
• Proteomics and Chemical Biology: Tool for labeling, crosslinking, or enriching proteins and other biomolecules for analytical studies.
• Diagnostic Assay Development: Fabrication of sensitive immunoassays or biosensors through controlled immobilization of capture molecules.

Basic Information

Product Name	1-Isothiocyanato-Peg3-Azide
CAS No.	1310686-23-7
Molecular Formula	C10H16N4O3S
Molecular Weight	272.33 g/mol
Synonyms	Azido-PEG3-isothiocyanate; 1-Azido-3,6,9-trioxa-12-isothiocyanatododecane; 17-Azido-3,6,9,12-tetraoxa-15-isothiocyanatoheptadecane; PEG3-Azide-NCS; N3-PEG3-NCS; Azido-PEG3-NCS; Isothiocyanato-PEG3-azide; 2,5,8,11-Tetraoxatetradecan-14-yl isothiocyanate, 13-azido-
EINECS	Contact for details

Quality Control

Our 1-Isothiocyanato-Peg3-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.