Description

4'-Hydroxy Torsemide-D7 is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise and reproducible results.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a quantitative reference standard in the bioanalysis of torsemide and its metabolites in biological matrices like plasma and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates accurate measurement of drug concentration and metabolic profiling in preclinical and clinical studies.
• Pharmaceutical Quality Control: Supports method development and validation for the assay of active pharmaceutical ingredients (APIs) and related substances.
• Clinical Research: Enables precise monitoring of drug levels in patients for therapeutic drug monitoring (TDM) and compliance studies.
• Reference Material for Certified Standards: Serves as a key component in the preparation of certified reference materials (CRMs) for regulatory submissions.

Basic Information

Product Name	4'-Hydroxy Torsemide-D7
CAS No.	1309935-97-4
Molecular Formula	C16H13D7N4O4S
Molecular Weight	349.42 g/mol
Synonyms	1-[4-[(3-Methylphenyl)amino]pyridine-3-sulfonyl]-3-(hydroxy-d7)urea; Torsemide Hydroxy Metabolite D7; Deuterated 4'-Hydroxy Torsemide; Torsemide D7 Metabolite; 4'-OH-Torsemide-d7; [D7]-4'-Hydroxytorsemide; 1-(4-((3-Methylphenyl)amino)-3-pyridinylsulfonyl)-3-(trideuteriomethoxy)urea
EINECS	Contact for details

Quality Control

Every batch of 4'-Hydroxy Torsemide-D7 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity, supported by advanced techniques including NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), and isotopic enrichment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.