Description

Tos-Peg2-T-Butyl Ester is a specialized bifunctional chemical building block featuring a tosylate leaving group and a protected carboxylic acid. This compound is engineered to provide controlled reactivity, making it a valuable intermediate for the precise synthesis of complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing drug conjugates, modifying biomolecules, and creating functionalized polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antibody-drug conjugates (ADCs), prodrugs, and targeted therapeutics.
• Bioconjugation: Used to attach polyethylene glycol (PEG) chains or other functional groups to peptides, proteins, and oligonucleotides to enhance solubility, stability, and pharmacokinetics.
• Polymer Chemistry: Serves as a functional monomer or initiator in the synthesis of tailored polymers with specific end-group functionality for material science applications.
• Linker Chemistry: Employed in the development of cleavable linkers for drug delivery systems and diagnostic assays.
• Chemical Biology Probes: Facilitates the creation of activity-based probes and labeling reagents for studying biological processes.
• Process Development: Used in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) requiring PEGylated intermediates.

Basic Information

Product Name	Tos-Peg2-T-Butyl Ester
CAS No.	1309666-78-1
Molecular Formula	C18H28O7S
Molecular Weight	388.48 g/mol
Synonyms	2-[2-(2-{[(4-Methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]acetic acid tert-butyl ester; tert-Butyl 2-[2-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]acetate; PEG2-tosylate tert-butyl ester; Tos-PEG2-OtBu; tert-Butyl-PEG2-tosylate; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of Tos-Peg2-T-Butyl Ester is manufactured under strict quality management protocols. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.