Description

Hydroxybupropion-D8 is a deuterium-labeled analog of the major active metabolite of the antidepressant and smoking cessation aid bupropion. This stable isotope-labeled compound is an essential reference standard and internal standard for precise analytical quantification. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development. The compound enables accurate and reliable measurement of bupropion and its metabolites in complex biological matrices.

Application

• Pharmacokinetic and Bioequivalence Studies: Serves as a critical internal standard in LC-MS/MS methods for quantifying bupropion and hydroxybupropion in plasma, serum, and urine.
• Drug Metabolism and Disposition (DMPK) Research: Used to trace metabolic pathways, study enzyme kinetics, and identify metabolites in in vitro and in vivo systems.
• Bioanalytical Method Development and Validation: Essential for developing robust, sensitive, and specific assays to support regulatory submissions (FDA, EMA).
• Clinical Trial Support: Ensures data accuracy in therapeutic drug monitoring and clinical pharmacology studies during drug development phases.
• Quality Control in Pharmaceutical Manufacturing: Can be used as a reference standard to assess the purity and stability of bupropion active pharmaceutical ingredient (API) and related products.
• Forensic and Toxicology Analysis: Aids in the precise identification and quantification of bupropion and its metabolites in forensic investigations.

Basic Information

Product Name	Hydroxybupropion-D8
CAS No.	1309283-18-8
Molecular Formula	C13H10D8ClNO
Molecular Weight	247.78 g/mol
Synonyms	(2S,3S)-Hydroxybupropion-d8; (1S,2S)-2-(3-Chlorophenyl)-2-hydroxy-3,5,5-trimethyl-D8-morpholin-2-one; 2-((1S,2S)-2-Hydroxy-3,5,5-trimethyl-D8-morpholin-2-yl)-3'-chloropropiophenone; Bupropion Metabolite Hydroxy-D8; (S,S)-Hydroxybupropion-d8; GSK-3,5,5-trimethyl-D8-morpholin-2-one; Deuterated Hydroxybupropion
EINECS	Contact for details

Quality Control

Our Hydroxybupropion-D8 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C) for structural confirmation and deuterium incorporation, HPLC for chemical purity, and MS for isotopic purity assessment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic enrichment, and residual solvents. Our quality commitment ensures the material is suitable for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.