Description

3-trans-Hydroxy Norcotinine is a high-purity, advanced pharmaceutical intermediate and metabolite of nicotine. This compound is of significant value for research and development in the fields of pharmacology and analytical chemistry. It serves as a critical reference standard and building block for scientists and manufacturers in the pharmaceutical, diagnostic, and life science industries.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of nicotine metabolites in pharmacokinetic and bioequivalence studies.
• Metabolite Research: Essential for investigating the metabolic pathways, biological activity, and clearance mechanisms of nicotine and related alkaloids.
• Diagnostic Kit Development: Acts as a key calibrant or antigen in the development of immunoassays and LC-MS/MS methods for clinical toxicology and nicotine exposure monitoring.
• Biochemical Research: Employed in studies exploring the interaction of nicotine derivatives with nicotinic acetylcholine receptors (nAChRs) and other biological targets.
• Impurity Profiling: Utilized as a known impurity standard in the quality control of nicotine-based pharmaceutical products and smoking cessation therapies.
• Forensic Analysis: Serves as a certified reference material for the accurate identification and quantification of substances in forensic toxicology.

Basic Information

Product Name	3-trans-Hydroxy Norcotinine
CAS No.	1292911-83-1
Molecular Formula	C9H12N2O2
Molecular Weight	180.21 g/mol
Synonyms	3-Hydroxy Norcotinine; trans-3'-Hydroxy Norcotinine; (R)-3-Hydroxy Norcotinine; 5-(3-Hydroxypyridin-2-yl)-1-methylpyrrolidin-2-one; Norcotinine-3-ol; Nicotine Metabolite; 3-Hydroxy-Nornicotine Enol Lactone; 2-Pyrrolidinone, 5-(3-hydroxy-2-pyridinyl)-1-methyl-, (5R)-
EINECS	Contact for details

Quality Control

Our 3-trans-Hydroxy Norcotinine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research and reference standard use. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.