Description

Creatinine-13C4 CAS NO 1286953-05-6 is a stable isotope-labeled analog of creatinine, where four carbon atoms are replaced with the Carbon-13 isotope. This compound is essential as an internal standard in quantitative mass spectrometry, enabling precise and accurate measurement of endogenous creatinine levels in complex biological matrices. It is a critical reagent for clinical diagnostics, pharmaceutical research, and metabolomic studies, where reliable quantification is paramount for assessing renal function, drug metabolism, and biomarker discovery.

Application

• Clinical Diagnostics & Research: Used as an internal standard in LC-MS/MS methods for the accurate quantification of creatinine in serum, plasma, and urine, supporting kidney function tests and disease monitoring.
• Pharmaceutical Development: Employed in pharmacokinetic and toxicokinetic studies to measure drug-induced changes in creatinine clearance and assess renal safety profiles of new drug candidates.
• Metabolomics & Biomarker Discovery: Serves as a critical reference compound in high-throughput metabolic profiling to normalize data and identify biomarkers related to renal and metabolic disorders.
• Sports Medicine & Doping Control: Applied in analytical methods to determine accurate creatinine levels, which are used to verify urine sample validity and detect adulteration.
• Reference Material Production: Utilized in the formulation of certified reference materials (CRMs) and quality control (QC) samples for clinical laboratory assays to ensure method accuracy and standardization across laboratories.
• Nutritional and Physiological Studies: Facilitates precise measurement of creatinine as an indicator of muscle mass and metabolic rate in nutritional and exercise science research.

Basic Information

Product Name	Creatinine-13C4
CAS No.	1286953-05-6
Molecular Formula	C13C3H7N3O
Molecular Weight	117.09 g/mol (for labeled form)
Synonyms	2-Amino-1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-one-13C4; 2-Amino-1-methyl-1H-imidazol-4-ol-13C4; 1-Methylglycocyamidine-13C4; 1-Methylhydantoin-2-imide-13C4; Creatinine-13C4; [13C4]-Creatinine; Isotopically Labeled Creatinine; Creatinine Internal Standard
EINECS	Contact for details

Quality Control

Our Creatinine-13C4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is thoroughly characterized using advanced techniques including NMR, HPLC, and mass spectrometry to confirm identity, purity, and isotopic enrichment. Certificates of Analysis (COA) are provided, detailing batch-specific results for critical parameters. We support compliance with relevant standards for reference materials used in clinical and pharmaceutical testing.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent absorption of atmospheric moisture, which could affect stability and analytical performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Isotopic Purity (by MS)	≥ 99% 13C4
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.