Description

Mal-Peg5-Acid CAS NO 1286755-26-7 is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group at one terminus and a carboxylic acid at the other, separated by a pentaethylene glycol spacer. This compound is a critical reagent for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and protein-polymer therapeutics. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors who require precise and reproducible conjugation chemistry to advance novel therapeutic and diagnostic platforms.

Application

• Antibody-Drug Conjugate (ADC) Development: Used as a key linker to covalently attach cytotoxic payloads to monoclonal antibodies via the maleimide-thiol chemistry, enabling targeted cancer therapies.
• Protein and Peptide PEGylation: Facilitates the site-specific modification of proteins and peptides through the carboxylic acid group, improving pharmacokinetic properties such as solubility, stability, and circulation half-life.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, or biosensor surfaces with maleimide groups for the subsequent immobilization of thiol-containing biomolecules.
• Crosslinking Reagent: Acts as a versatile crosslinker for coupling amines (via the acid group) and thiols (via the maleimide group) in the construction of complex biomolecular assemblies and hydrogels.
• Diagnostic Reagent Synthesis: Integral in the production of enzyme conjugates, fluorescent probes, and other diagnostic reagents that require stable, defined linkages.
• Biomaterial Engineering: Used to incorporate bioactive ligands into polymeric biomaterials to control cell-material interactions for tissue engineering and regenerative medicine applications.

Basic Information

Product Name	Mal-Peg5-Acid
CAS No.	1286755-26-7
Molecular Formula	C24H41NO12
Molecular Weight	535.59 g/mol
Synonyms	Maleimide-PEG5-acid; 3-(2,5,8,11,14-Pentaoxahexadecan-16-yl)-1H-pyrrole-2,5-dione-1-propanoic acid; Maleimide-Pentaethylene glycol-acid; Mal-PEG5-COOH; 1H-Pyrrole-2,5-dione, 3-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-; Maleimide-PEG5-propionic acid; NHS-PEG5-Maleimide precursor; Heterobifunctional PEG linker, Mal-PEG5-COOH
EINECS	Contact for details

Quality Control

Our Mal-Peg5-Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive bioconjugation applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We support cGMP manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (H-NMR)	Conforms to structure
Identification (Mass Spec)	Conforms (M+Na+ or M+H+)
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.