Description

3-Hydroxy Lidocaine-D5 is a deuterium-labeled internal standard critical for ensuring the accuracy and reliability of quantitative bioanalytical methods. This high-purity compound is essential for researchers and quality control laboratories requiring precise measurement of its non-labeled counterpart, 3-Hydroxy Lidocaine, in complex biological matrices. It is primarily used in pharmaceutical development, forensic toxicology, and clinical research for method validation and pharmacokinetic studies.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS assays for the accurate quantification of 3-Hydroxy Lidocaine in plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug metabolism and clearance rates in preclinical and clinical research.
• Forensic Toxicology: Used in confirmatory testing and method development for the detection of lidocaine metabolites in forensic applications.
• Pharmaceutical Quality Control: Supports impurity profiling and assay validation for lidocaine and related pharmaceutical products.
• DMPK (Drug Metabolism and Pharmacokinetics): A vital tool in drug discovery and development for understanding the metabolic fate of lidocaine analogs.

Basic Information

Product Name	3-Hydroxy Lidocaine-D5
CAS No.	1286482-71-0
Molecular Formula	C14H17D5N2O2
Molecular Weight	247.36 g/mol
Synonyms	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide-3-hydroxy-d5; Lidocaine Hydroxy Metabolite-d5; 3-Hydroxylidocaine-d5; Monohydroxylidocaine-d5; 2-Diethylamino-2',6'-acetoxylidide-3-hydroxy-d5; 3-OH-Lidocaine-d5; Deuterated 3-Hydroxy Lidocaine; Lidocaine-d5 Metabolite
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxy Lidocaine-D5 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity to meet the exacting standards of analytical research. A detailed Certificate of Analysis (COA), including data for purity (HPLC), isotopic enrichment (MS), and identification (NMR/IR), is provided with each shipment to ensure full traceability and compliance with your protocol requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.