Description

4,7,10,13,16,19,22,25-Octaoxa-28-Azatriacontanoic Acid, 30-Bromo-29-Oxo-, 2,5-Dioxo-1-Pyrrolidinyl Ester is a specialized heterobifunctional PEG-based crosslinking reagent featuring a reactive NHS ester and a bromoacetyl group. This compound is engineered for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined constructs. It is primarily utilized by researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science where precise molecular assembly is critical.

Application

• Bioconjugation and Protein Modification: Used to create covalent linkages between peptides, proteins, and other biomolecules via amine-reactive NHS ester and thiol-reactive bromoacetyl groups.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a functionalized PEG spacer in the synthesis of ADCs, improving solubility and pharmacokinetics.
• Surface Functionalization: Immobilizes biomolecules onto nanoparticles, biosensors, and diagnostic assay platforms.
• Polymer Chemistry: Acts as a heterobifunctional initiator or crosslinker for synthesizing functionalized PEG-based hydrogels and smart materials.
• Diagnostic Reagent Synthesis: Employed in the development of labeled probes and contrast agents for imaging and detection.
• Drug Delivery System Development: Facilitates the attachment of targeting ligands or therapeutic payloads to carrier systems.

Basic Information

Product Name	4,7,10,13,16,19,22,25-Octaoxa-28-Azatriacontanoic Acid, 30-Bromo-29-Oxo-, 2,5-Dioxo-1-Pyrrolidinyl Ester
CAS No.	1283658-79-6
Molecular Formula	C₂₆H₄₅BrN₂O₁₂
Molecular Weight	645.55 g/mol
Synonyms	NHS-PEG₈-Bromoacetamide; Bromoacetyl-PEG₈-NHS Ester; α-Bromoacetamido-ω-succinimidyl ester octaethylene glycol; Bromoacetyl-PEG8-NHS; 30-Bromo-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azatriacontan-1-oic acid 2,5-dioxopyrrolidin-1-yl ester; Heterobifunctional PEG linker NHS-PEG8-Br; PEG-based crosslinker CAS 1283658-79-6
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical reagent adheres to stringent quality management systems. Every batch is characterized and tested to ensure consistent reactivity and purity, critical for reproducible research and development outcomes. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the active ester. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (NHS Ester)	≥ 90%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.