Description

Quinaprilat-D5 is a deuterium-labeled analog of the active metabolite of the antihypertensive drug Quinapril. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods. It serves as a critical internal standard in pharmacokinetic and metabolic studies, primarily within the pharmaceutical research and development sector. Professionals in analytical chemistry and drug discovery rely on it for precise LC-MS/MS analysis.

Application

• Primary use as an internal standard for the quantification of Quinapril and Quinaprilat in biological matrices via LC-MS/MS.
• Supporting pharmacokinetic (PK) and bioequivalence studies in clinical and preclinical research.
• Facilitating drug metabolism and disposition (DMPK) investigations.
• Enhancing method validation and ensuring regulatory compliance in bioanalytical method development.
• Application in isotope dilution mass spectrometry for high-precision measurements.
• Use in quality control laboratories for reference standard preparation.

Basic Information

Product Name	Quinaprilat-D5
CAS No.	1279034-23-9
Molecular Formula	C25H25D5N2O5
Molecular Weight	447.53 g/mol (for D5 labeled form)
Synonyms	(3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic-3,5,6,7,8-d5 Acid; Deuterated Quinaprilat; Quinaprilat-d5; [3,5,6,7,8-2H5]-Quinaprilat; (S)-N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic-3,5,6,7,8-d5 Acid; Stable Isotope Labeled Quinaprilat Metabolite
EINECS	Contact for details

Quality Control

Our Quinaprilat-D5 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment, chemical purity, and confirming identity. We support compliance with GLP/GMP guidelines for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (MS)	≥98.0 atom % D
Isotopic Enrichment	≥95% D5 (by MS)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.