Description

n-Acetyl-S-Ethyl-L-Cysteine-D5 is a deuterated isotopologue of the endogenous metabolite N-acetyl-S-ethyl-L-cysteine, specifically designed for use as a high-purity internal standard in quantitative analytical methods. This compound is critical for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical R&D departments engaged in advanced bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of N-acetyl-S-ethyl-L-cysteine and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track the metabolic fate and clearance rates of parent compounds, providing critical data for drug development.
• Biomarker Research and Validation: Enables accurate measurement of specific mercapturic acid pathway metabolites as biomarkers of exposure to certain xenobiotics or in disease state profiling.
• Toxicological and Environmental Monitoring: Supports assays designed to monitor human exposure to specific industrial chemicals or environmental toxins by quantifying their stable metabolite derivatives.
• High-Purity Reference Material: Serves as a certified reference standard for calibrating analytical instruments and validating testing protocols in GLP/GMP-compliant laboratories.

Basic Information

Product Name	n-Acetyl-S-Ethyl-L-Cysteine-D5
CAS No.	1279033-91-8
Molecular Formula	C7H8D5NO3S
Molecular Weight	207.28 g/mol (for deuterated form)
Synonyms	N-Acetyl-S-ethyl-L-cysteine-d5; N-Acetyl-S-ethylcysteine-d5; Acetyl-S-ethylcysteine-d5; S-Ethyl-N-acetyl-L-cysteine-d5; N-Acetyl-3-[(ethyl-d5)thio]-L-alanine; 2-(Acetylamino)-3-[(ethyl-d5)sulfanyl]propanoic acid; AEC-D5; NAEC-D5; Deuterated N-Acetyl-S-ethyl-L-cysteine
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-S-Ethyl-L-Cysteine-D5 is manufactured and tested under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards for reference materials. Certificates of Analysis (COA) detailing batch-specific results for identity, purity (HPLC), isotopic enrichment (NMR/MS), and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.