Description

Dothiepin-D6 Hcl (N,n-Dimethyl-D6) (Cis/Trans Mixture) is a deuterated isotopologue of the tricyclic antidepressant dothiepin, specifically labeled at the N,N-dimethyl positions. This compound is a critical internal standard for the precise quantification of dothiepin in complex matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors, ensuring accurate pharmacokinetic studies, metabolism research, and regulatory compliance testing. The product is supplied as a mixture of cis and trans isomers, reflecting the stereochemistry of the parent compound.

Application

• Internal Standard for Bioanalytical Assays: Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the accurate quantification of dothiepin in biological samples (plasma, serum, urine).
• Pharmaceutical Research & Development: Enables precise pharmacokinetic (PK) and pharmacodynamic (PD) studies, metabolism profiling, and drug interaction investigations during drug development.
• Forensic and Clinical Toxicology: Critical for the reliable detection and measurement of dothiepin in forensic analysis, therapeutic drug monitoring (TDM), and overdose cases.
• Reference Standard for Quality Control: Serves as a certified reference material (CRM) for method validation, calibration, and ensuring the accuracy and precision of analytical methods in QC laboratories.
• Metabolite Studies: Used in the identification and quantification of dothiepin metabolites in in vitro and in vivo studies.
• Regulatory Compliance Testing: Supports analytical testing required for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Dothiepin-D6 Hcl (N,n-Dimethyl-D6) (Cis/Trans Mixture)
CAS No.	1276545-35-7
Molecular Formula	C19H15D6ClNS
Molecular Weight	Approx. 345.95 g/mol
Synonyms	Dothiepin-d6 hydrochloride; Dothiepin (N,N-dimethyl-d6) hydrochloride; 11-(3-Dimethylamino-d6-propylidene)-6H-dibenzo[b,e]thiepin hydrochloride; Prothiaden-d6 HCl; Dosulepin-d6 hydrochloride; 1-Propanamine, 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-d6-, hydrochloride; Dothiepin D6 Internal Standard
EINECS	Contact for details

Quality Control

Our Dothiepin-D6 HCl is manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch is subjected to rigorous analytical testing, including NMR (1H, 13C), Mass Spectrometry (MS), and High-Performance Liquid Chromatography (HPLC/UPLC) to confirm identity, chemical purity, isotopic enrichment (≥98 atom % D), and isomeric ratio. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Isomeric Ratio (Cis/Trans)	As per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.