Description

Zanamivir-13C,15N2 is a stable isotope-labeled analog of the antiviral drug Zanamivir, specifically enriched with carbon-13 and nitrogen-15 isotopes. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical research and development, clinical diagnostics, and forensic analysis laboratories focused on influenza antivirals.

Application

• Quantitative Bioanalysis: Serves as a primary internal standard in LC-MS/MS and GC-MS methods for the precise quantification of Zanamivir in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of drug metabolites by providing a stable isotopic reference point.
• Method Development and Validation: Critical for developing robust, regulatory-compliant analytical methods (following FDA, EMA, ICH guidelines) for drug substance and product testing.
• Clinical Diagnostic Assays: Used in specialized diagnostic tests to monitor drug levels in patients, supporting personalized medicine approaches.
• Forensic and Doping Control Analysis: Provides definitive identification and quantification in forensic toxicology and anti-doping programs.
• Reference Material Production: Acts as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity across laboratories.

Basic Information

Product Name	Zanamivir-13C,15N2
CAS No.	1276528-62-1
Molecular Formula	C1213CH22N315N2O7
Molecular Weight	335.30 g/mol (labeled)
Synonyms	5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-[(1S,2R)-1,2,3-trihydroxy-2-(phosphonooxy)propyl]-D-glycero-D-galacto-non-2-enonic acid-13C,15N2; (2R,3R,4S)-3-Acetamido-4-guanidino-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid-13C,15N2; GG167-13C,15N2; Isotopically Labeled Zanamivir; Zanamivir Internal Standard; [13C,15N2]-Zanamivir; Zanamivir (13C,15N2)
EINECS	Contact for details

Quality Control

Every batch of Zanamivir-13C,15N2 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (1H, 13C), Mass Spectrometry, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (HPLC), isotopic enrichment, and other critical parameters to ensure compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.