Description

m-Peg4-Mal CAS NO 1263044-81-0 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group at one terminus and a methoxy group at the other, separated by a tetraethylene glycol spacer. This compound is essential for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and other therapeutic biologics. It is a critical reagent for researchers and manufacturers in biopharmaceuticals, diagnostics, and advanced materials science who require precise and reliable conjugation chemistry.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to antibodies via thiol-maleimide chemistry.
• PEGylation of Proteins and Peptides: Introduction of a hydrophilic PEG spacer to improve pharmacokinetics, solubility, and stability of therapeutic biomolecules.
• Surface Functionalization: Modification of nanoparticles, biosensors, and solid supports for targeted binding and assay development.
• Crosslinking Agent: For creating hydrogels or crosslinked polymer networks with controlled mesh sizes and properties.
• Diagnostic Probe Conjugation: Linking fluorescent dyes, enzymes, or other reporter molecules to targeting ligands like antibodies or peptides.
• Biomaterial Engineering: Fabrication of functionalized scaffolds for tissue engineering and controlled drug delivery systems.

Basic Information

Product Name	m-Peg4-Mal
CAS No.	1263044-81-0
Molecular Formula	C18H31NO9
Molecular Weight	405.44 g/mol
Synonyms	mPEG4-Maleimide; Methoxy-PEG4-maleimide; Maleimide-PEG4-OMe; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 14-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-α-methoxy-ω-oxo-; 1-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl]-1H-pyrrole-2,5-dione; PEG4-Maleimide Methyl Ether
EINECS	Contact for details

Quality Control

Our m-Peg4-Mal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.