Description

Biotin-Peg3-Alcohol CAS NO 1263044-40-1 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin group for affinity binding and a terminal hydroxyl group for further conjugation. This compound is critical for creating stable, site-specific bioconjugates used in advanced diagnostic and therapeutic platforms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent industries for applications such as probe labeling, drug delivery system development, and surface functionalization.

Application

• Bioconjugation and Probe Development: Used to attach biotin tags to antibodies, proteins, or oligonucleotides for use in ELISA, Western blotting, and other detection assays.
• Drug Delivery Systems: Serves as a key building block in the synthesis of biotinylated lipid nanoparticles (LNPs) or polymer-drug conjugates for targeted delivery.
• Surface Functionalization: Employed to modify sensor chips, magnetic beads, or microplates with biotin, enabling the capture of streptavidin-linked molecules in biosensors and purification systems.
• ADC (Antibody-Drug Conjugate) Linker Chemistry: Acts as a spacer in the construction of ADCs, connecting cytotoxic payloads to targeting antibodies via its functional groups.
• Chemical Biology Tool: Facilitates the study of protein-protein interactions and cellular processes through biotin-streptavidin technology.
• Diagnostic Reagent Synthesis: A crucial intermediate in manufacturing high-sensitivity diagnostic kits and imaging agents.

Basic Information

Item	Details
Product Name	Biotin-Peg3-Alcohol
CAS No.	1263044-40-1
Molecular Formula	C20H36N4O7S
Molecular Weight	476.59 g/mol
Synonyms	Biotin-PEG3-OH; Biotin-triethylene glycol alcohol; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide; Biotinamido-PEG3-alcohol; Biotin-PEG3-alcohol; Biotinylated PEG3 alcohol; Biotin-PEG3 linker with hydroxyl group
EINECS	Contact for details

Quality Control

Our Biotin-Peg3-Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.