Description

T-Boc-n-Amido-Peg6-Propargyl is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (BOC)-protected amine at one terminus and a propargyl group at the other. This compound is essential for creating stable, cleavable, and bioorthogonal conjugates in advanced bioconjugation and materials science. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing novel drug delivery systems, bioconjugates, and functionalized surfaces.

Application

• ADC (Antibody-Drug Conjugate) Development: As a key linker component for attaching cytotoxic payloads to monoclonal antibodies via click chemistry and amine coupling strategies.
• PEGylation Reagent: For introducing hydrophilic PEG spacers to peptides, proteins, or small molecules to enhance solubility, stability, and pharmacokinetic profiles.
• Click Chemistry Substrate: The propargyl group enables efficient, site-specific conjugation with azide-functionalized molecules in copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions.
• Surface Functionalization: For modifying nanoparticles, biosensors, or chromatography media to create reactive surfaces for further biomolecule immobilization.
• Protease-Cleavable Linker Synthesis: The amide bond within the structure can be designed as part of a peptide sequence cleavable by specific enzymes for targeted drug release.
• Crosslinking Agent: Used in polymer chemistry and hydrogel formation to create networks with controlled degradation properties.

Basic Information

Product Name	T-Boc-n-Amido-Peg6-Propargyl
CAS No.	1262991-52-5
Molecular Formula	C28H53N3O10
Molecular Weight	591.74 g/mol
Synonyms	1-Boc-3,6,9,12,15,18-hexaoxa-21-azatetratriacont-33-yn-22-one; 2,5,8,11,14,17-Hexaoxa-20-azadotriacont-30-yn-21-oic acid, 1,1-dimethylethyl ester; BOC-NH-PEG6-PROPARGYL; tert-Butyl (1-(2-(2-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylamino)-1-oxo-5,8,11,14,17,20-hexaoxa-2-azadocosan-22-yl)carbamate; Propargyl-PEG6-amine-Boc; BOC-Amine-PEG6-Propargyl; Amino-PEG6-Propargyl, BOC protected; Heterobifunctional PEG linker BOC-NH-PEG6-alkyne
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg6-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. For long-term storage, desiccate. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.