Description

Propionylpromazine-D6 Hydrochloride is a high-purity, deuterium-labeled internal standard critical for modern analytical chemistry. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and forensic toxicology units for method development, validation, and routine testing.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the precise quantification of promazine and related phenothiazine derivatives in complex biological matrices.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in the development and execution of confirmatory assays for antipsychotic drug screening and monitoring in forensic and clinical settings.
• Pharmaceutical Quality Control: Supports impurity profiling and assay validation for active pharmaceutical ingredients (APIs) and finished drug products containing phenothiazines.
• Biomarker Research: Facilitates the accurate measurement of endogenous or drug-related metabolites in biomarker discovery and validation pipelines.
• Regulatory Submissions: Provides the traceable, high-quality reference material required for compliant data packages submitted to agencies like the FDA and EMA.

Basic Information

Product Name	Propionylpromazine-D6 Hydrochloride
CAS No.	1262770-67-1
Molecular Formula	C20H17D6ClN2OS
Molecular Weight	380.96 g/mol
Synonyms	10-[3-(Dimethylamino)propyl]-2-(trideuteriomethyl)phenothiazin-10-ium-1-propionyl chloride; Promazine-D6 Propionyl Chloride; N-Propionylpromazine-D6 Hydrochloride; Deuterated Propionylpromazine HCl; Propionylpromazine-d6 HCl; Internal Standard for Promazine; Phenothiazine-d6 Derivative
EINECS	Contact for details

Quality Control

Every batch of Propionylpromazine-D6 Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity to meet the exacting demands of quantitative bioanalysis. A detailed Certificate of Analysis (COA), including data for assay, isotopic enrichment, and impurity profile, is provided with each shipment to ensure full traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.