Description

Pazopanib 13C D3 Hydrochloride is a stable isotope-labeled analog of the multi-tyrosine kinase inhibitor Pazopanib, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity reference material is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolic data in drug development. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in advanced LC-MS/MS method development and validation.

Application

• Quantitative Bioanalysis: Serves as an essential internal standard for the precise quantification of Pazopanib and its metabolites in biological matrices (e.g., plasma, serum, tissue) using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate studies on absorption, distribution, metabolism, and excretion (ADME) of Pazopanib in preclinical and clinical research.
• Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with GLP and ICH guidelines.
• Clinical Trial Support: Used in bioanalytical assays to monitor drug concentration levels in patients during clinical trials for cancer therapeutics.
• Impurity Profiling and Characterization: Aids in the identification and quantification of related substances and degradation products in drug substance and product analysis.

Basic Information

Product Name	Pazopanib 13C D3 Hydrochloride
CAS No.	1261398-44-0
Molecular Formula	C₂₁H₂₀¹³C D₃N₇O·HCl
Molecular Weight	Contact for details
Synonyms	Pazopanib-13C,d3 Hydrochloride; GW786034-13C D3 Hydrochloride; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide-13C,d3 Hydrochloride; Votrient-13C D3 Hydrochloride (Labeled); Pazopanib (phenyl-13C,d3) Hydrochloride; Pazopanib Internal Standard-13C D3; Pazopanib Isotopically Labeled Standard
EINECS	Contact for details

Quality Control

Our Pazopanib 13C D3 Hydrochloride is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by MS and NMR). We adhere to relevant guidelines for reference standards to support your GLP/GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99.0 atom % 13C; ≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.