Description

4'-Hydroxyphenyl Carvedilol-D5 is a deuterated analog of a key carvedilol metabolite, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity reference material is essential for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolism research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing for cardiovascular therapeutics.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of 4'-Hydroxyphenyl Carvedilol and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical trials.
• Metabolite Profiling & Identification: Serves as a reference compound for elucidating the metabolic pathways of carvedilol in vivo.
• Bioanalytical Method Development & Validation: Used to establish and validate robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Doping Control & Forensic Analysis: Supports the detection and confirmation of carvedilol and its metabolites in sports doping and forensic toxicology investigations.
• Quality Control in Reference Material Production: Acts as a calibrant for the certification of non-deuterated metabolite reference standards.

Basic Information

Product Name	4'-Hydroxyphenyl Carvedilol-D5
CAS No.	1261395-96-3
Molecular Formula	C24H21D5N2O5
Molecular Weight	~427.5 g/mol
Synonyms	1-(9H-Carbazol-4-yloxy)-3-[[2-(2-deuteriomethoxy-4,6-bis(deuteriomethyl)phenoxy)ethyl]amino]-2-propanol-D3; Carvedilol D5 Metabolite; 4'-OH Carvedilol-D5; 1-(Carbazol-4-yloxy)-3-[[2-(2-methoxy-4,6-dimethylphenoxy)ethyl]amino]-2-propanol-d5 (4'-Hydroxy); Deuterated 4'-Hydroxy Carvedilol; Carvedilol Hydroxy Phenyl D5; 4'-Hydroxy Carvedilol Deuterated Internal Standard
EINECS	Contact for details

Quality Control

Our 4'-Hydroxyphenyl Carvedilol-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to primary reference standards. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chemical Purity (NMR)	Conforms
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.