Description

Estrone, 3-Methyl-[13C,D3] Ether is a high-purity, stable isotope-labeled derivative of the natural estrogen, estrone. This compound is specifically engineered for use as a critical internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and environmental monitoring sectors who require definitive quantification of estrogenic compounds.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the precise quantification of estrone and related metabolites in complex biological matrices.
• Pharmaceutical R&D and Bioanalysis: Used in pharmacokinetic and pharmacodynamic studies to track drug metabolism and hormone levels with high specificity and minimal interference.
• Clinical Diagnostics and Endocrinology: Enables accurate measurement of estrogen levels in serum, plasma, and urine for hormone disorder diagnosis and therapeutic monitoring.
• Environmental and Food Safety Testing: Facilitates the detection and quantification of trace-level estrogenic endocrine disruptors in water, soil, and food products.
• Metabolomics and Biomarker Discovery: Provides a stable reference point in high-throughput profiling of steroid hormone pathways.
• Method Development and Validation: Essential for developing, calibrating, and validating robust analytical methods to meet regulatory standards (FDA, EMA).

Basic Information

Product Name	Estrone, 3-Methyl-[13C,D3] Ether
CAS No.	1261254-60-7
Molecular Formula	C1913CH23D3O2
Molecular Weight	~274.4 g/mol
Synonyms	3-Methoxyestra-1,3,5(10)-trien-17-one-19-13C,3-O-methyl-d3; [19-13C,3-O-methyl-d3]-Estrone 3-methyl ether; 3-Methoxy-13C,d3-estrone; Labeled Estrone 3-Methyl Ether; Stable Isotope-Labeled Estrone Derivative; Internal Standard for Estrogen Analysis; Estrone-d3-13C Methyl Ether
EINECS	Contact for details

Quality Control

Every batch of Estrone, 3-Methyl-[13C,D3] Ether is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity through rigorous testing via NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.