Description

Aldosterone (2,2,4,6,6,17,21,21-D8) CAS NO 1261254-31-2 is a deuterium-labeled analog of the essential mineralocorticoid hormone aldosterone. This high-purity, isotopically labeled standard is critical for ensuring analytical accuracy and reliability in quantitative mass spectrometry. It is primarily required by pharmaceutical research laboratories, clinical diagnostic developers, and academic institutions engaged in endocrinology and metabolomics studies.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative reference for the accurate measurement of endogenous aldosterone levels in biological matrices such as plasma, serum, and urine.
• Clinical Diagnostics: Used in the development and validation of high-sensitivity assays for conditions like primary aldosteronism (Conn's syndrome) and other disorders of the renin-angiotensin-aldosterone system (RAAS).
• Metabolomics & Biomarker Research: Enables precise tracking and quantification in studies investigating steroid hormone pathways, metabolic diseases, and drug effects.
• Pharmaceutical R&D: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies for drugs targeting mineralocorticoid receptors or steroidogenesis.
• Reference Material: Acts as a certified standard for calibrating analytical instruments and validating method performance in GLP/GMP-compliant environments.

Basic Information

Product Name	Aldosterone (2,2,4,6,6,17,21,21-D8)
CAS No.	1261254-31-2
Molecular Formula	C21H20D8O5
Molecular Weight	~368.48 g/mol
Synonyms	11β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al (2,2,4,6,6,17,21,21-D8); [2,2,4,6,6,17,21,21-D8]-Aldosterone; Deuterated Aldosterone; Aldosterone-d8; 11β,21-Dihydroxy-18-oxopregn-4-ene-3,20-dione-d8; 18-Oxocorticosterone-d8
EINECS	Contact for details

Quality Control

Our deuterated standards are produced and controlled under a strict quality management system. Each batch undergoes comprehensive analysis to ensure high chemical and isotopic purity, typically exceeding 98% (by HPLC and NMR). Certificates of Analysis (COA) are provided, detailing results for assay, isotopic enrichment, and specific tests. We support GMP/GLP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.