Description

n-(Acetyl-D3)-S-(2-Carboxyethyl)-L-Cysteine is a stable isotope-labeled analog of the mercapturic acid metabolite of acrolein, a reactive aldehyde of toxicological significance. This deuterated compound is an essential reference standard and internal standard for accurate quantitative analysis in mass spectrometry-based assays. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in advanced biomarker research, toxicology studies, and drug metabolism and pharmacokinetics (DMPK) investigations.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the precise LC-MS/MS quantification of S-(3-hydroxypropyl)mercapturic acid (HPMA), the major urinary metabolite of acrolein.
• Biomarker Validation: Enables accurate measurement of acrolein exposure in biological matrices (urine, plasma) for studies on oxidative stress, smoking-related diseases, and environmental toxicity.
• Toxicology and Exposure Assessment: Used in research to assess human exposure to acrolein from dietary sources, tobacco smoke, and industrial processes.
• Drug Development Studies: Facilitates DMPK studies for drugs that may generate or interact with reactive aldehydes, ensuring reliable metabolite tracking.
• Clinical Research: Supports clinical trials investigating the role of acrolein and lipid peroxidation in pathologies like cancer, neurodegenerative disorders, and cardiovascular disease.
• Method Development and GLP Compliance: Essential for developing, validating, and conducting bioanalytical methods under Good Laboratory Practice (GLP) guidelines.

Basic Information

Product Name	n-(Acetyl-D3)-S-(2-Carboxyethyl)-L-Cysteine
CAS No.	1260619-43-9
Molecular Formula	C8H10D3NO5S
Molecular Weight	238.27 g/mol
Synonyms	N-Acetyl-S-(2-carboxyethyl)-L-cysteine-d3; N-Acetyl-S-(2-carboxyethyl)-L-cysteine (acetyl-d3); N-Acetyl-3-(propyl-d3)-L-cysteine; Acrolein Mercapturic Acid-d3 (Acetyl-d3); HPMA Internal Standard-d3; S-(3-Hydroxypropyl)-N-acetyl-L-cysteine-d3 (Acetyl-d3); Deuterated Acrolein Metabolite Standard; L-Cysteine, N-acetyl-3-(propyl-d3)-
EINECS	Contact for details

Quality Control

Every batch of n-(Acetyl-D3)-S-(2-Carboxyethyl)-L-Cysteine is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (¹H, ¹³C), Mass Spectrometry, and HPLC. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and all specification parameters are provided to ensure traceability and compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D (by MS)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.