Description

2,5-Dioxopyrrolidin-1-Yl 3-(2-(3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanamido)Ethoxy)Propanoate is a specialized heterobifunctional crosslinking agent designed for advanced bioconjugation and material science applications. This compound is engineered to provide a robust and selective method for covalently linking biomolecules or polymers under mild conditions. It is an essential reagent for researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced polymer synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: Used to attach fluorescent dyes, biotin, or other reporter molecules to proteins for detection and purification.
• Surface Functionalization: Enables the covalent immobilization of biomolecules onto sensor chips, nanoparticles, or chromatography resins for biosensors and affinity purification.
• Polymer Crosslinking: Serves as a reactive moiety for creating hydrogels or modifying polymer backbones to introduce specific functional groups.
• Diagnostic Reagent Synthesis: Critical in the manufacture of conjugated antigens or antibodies used in ELISA, lateral flow assays, and other immunoassays.
• Biomaterial Engineering: Facilitates the creation of bioactive scaffolds for tissue engineering by linking growth factors or cell-adhesion peptides.

Basic Information

Item	Details
Product Name	2,5-Dioxopyrrolidin-1-Yl 3-(2-(3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanamido)Ethoxy)Propanoate
CAS No.	1260092-50-9
Molecular Formula	C16H17N3O8
Molecular Weight	379.32 g/mol
Synonyms	NHS-PEG2-Maleimide; Maleimide-PEG2-NHS ester; SM(PEG)2; 1-[3-(2-{3-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)]propanamido}ethoxy)propanoyl]pyrrolidine-2,5-dione; 3-(2-(3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; N-(2-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide active ester; Heterobifunctional PEG crosslinker, NHS-PEG2-MAL
EINECS	Contact for details

Quality Control

Every batch of our 2,5-Dioxopyrrolidin-1-Yl 3-(2-(3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanamido)Ethoxy)Propanoate is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the high purity and consistent reactivity required for sensitive bioconjugation workflows. Certificates of Analysis (COA) detailing purity, identity, and functional group integrity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.