Description

3-[[2-(Biotinamido)Ethyl]Dithio]Propionic Acid 4'-(Hydroxymethyl)Dmpo Ester is a sophisticated, heterobifunctional crosslinking reagent designed for advanced bioconjugation and labeling applications. Its core value lies in the precise, reversible linkage it provides between biomolecules, enabled by its cleavable disulfide bridge and photoreactive ester group. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation who require controlled and reversible attachment strategies.

Application

• Bioconjugation and Crosslinking: For the reversible, site-specific conjugation of proteins, peptides, antibodies, or other biomolecules via disulfide bond formation.
• Affinity Chromatography: As a cleavable linker for immobilizing ligands (e.g., biotinylated molecules) onto solid supports for protein purification.
• Drug Delivery Systems: In the development of targeted therapeutics where a cleavable linker is required for payload release in specific cellular environments.
• Proteomic Research: For labeling and capturing protein complexes or studying protein-protein interactions with the option for controlled elution.
• Diagnostic Reagent Synthesis: In the manufacture of enzyme-linked or fluorescent immunoassay components that benefit from reversible binding properties.
• Surface Functionalization: To create modified surfaces (e.g., biosensor chips) with cleavable capture agents for analyte detection and recovery.

Basic Information

Product Name	3-[[2-(Biotinamido)Ethyl]Dithio]Propionic Acid 4'-(Hydroxymethyl)Dmpo Ester
CAS No.	1255087-87-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Biotin-HPDP Ester; Biotin-HPDP; 3-((2-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)dithio)propionic acid 4'-(hydroxymethyl)dmpo ester; DMPO-Biotin-HPDP; Cleavable Biotinylation Reagent; Heterobifunctional Biotin Crosslinker; Biotinylated Disulfide Linker; Biotin-HPDP Photoreactive Ester
EINECS	Contact for details

Quality Control

Our 3-[[2-(Biotinamido)Ethyl]Dithio]Propionic Acid 4'-(Hydroxymethyl)Dmpo Ester is manufactured under strict quality systems suitable for research and development use. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and structural confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. This compound is easily oxidized; store under an inert atmosphere when possible after initial opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.