Description

Vatalanib-D4 Dihydrochloride is a deuterated isotopologue of the potent vascular endothelial growth factor receptor (VEGFR) inhibitor, Vatalanib. This high-purity reference standard is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies in drug development. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in deuterium-labeled internal standards for mass spectrometry.

Application

• As a deuterated internal standard for the precise quantification of Vatalanib in biological matrices using LC-MS/MS.
• For conducting metabolic stability studies and ADME (Absorption, Distribution, Metabolism, and Excretion) profiling in preclinical research.
• In bioanalytical method development and validation to meet regulatory requirements for assay specificity and accuracy.
• Supporting pharmacokinetic (PK) and pharmacodynamic (PD) studies during clinical trial phases.
• Used in drug metabolism research to elucidate metabolic pathways and identify metabolites.
• As a critical component in quality control for the production and analysis of Vatalanib active pharmaceutical ingredient (API).

Basic Information

Product Name	Vatalanib-D4 Dihydrochloride
CAS No.	1246820-27-8
Molecular Formula	C₂₀H₁₁D₄Cl₂N₅O
Molecular Weight	424.30 g/mol
Synonyms	PTK787 D4 Dihydrochloride; ZK 222584 D4 Dihydrochloride; N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine-d4 Dihydrochloride; 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, D4 Dihydrochloride; Vatalanib (D4) Dihydrochloride; CGP 79787D D4 Dihydrochloride; PTK787 ZK 222584 D4 Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of Vatalanib-D4 Dihydrochloride is manufactured and tested under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Our quality protocols are designed to meet the rigorous demands of pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and identity are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.