Description

Rac-Trans 3’-Thiomethyl Nicotine Dihydrochloride is a high-purity, synthetic nicotine derivative of significant interest in advanced chemical research and development. This compound serves as a critical intermediate and reference standard for the study of nicotinic acetylcholine receptor (nAChR) interactions and metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and specialty chemical manufacturers focused on neuroscience and addiction research.

Application

• Pharmaceutical Reference Standard: Used as a certified analytical standard for method development, validation, and quality control in the analysis of nicotine analogs and related substances.
• Neuroscience Research: A key intermediate in the synthesis of novel compounds for studying the structure-activity relationships (SAR) of nicotinic receptor ligands.
• Metabolic Pathway Studies: Employed in biochemical research to investigate the metabolism and pharmacokinetics of modified nicotine derivatives.
• Analytical Chemistry: Serves as a critical reagent for calibrating instruments like HPLC, LC-MS, and GC-MS in forensic and toxicology laboratories.
• Chemical Synthesis: Acts as a versatile building block for the preparation of more complex, targeted molecules for pharmacological evaluation.

Basic Information

Product Name	Rac-Trans 3’-Thiomethyl Nicotine Dihydrochloride
CAS No.	1246820-13-2
Molecular Formula	C11H17Cl2N2S
Molecular Weight	280.24 g/mol
Synonyms	3'-Thiomethyl Nicotine Dihydrochloride (Racemic Trans); (±)-Trans-3'-(Methylthio)nicotine Dihydrochloride; Rac-Trans-3'-Methylthionicotine Dihydrochloride; 1-Methyl-2-(3-methylthio-3-pyridyl)pyrrolidine Dihydrochloride; Nicotine 3'-Methyl Thioether Dihydrochloride (Racemic Trans); trans-3'-(Methylsulfanyl)nicotine Dihydrochloride (Racemic); 3'-Methylmercaptonicotine Dihydrochloride (Racemic Trans Isomer)
EINECS	Contact for details

Quality Control

Our Rac-Trans 3’-Thiomethyl Nicotine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment to maintain stability and purity. Avoid prolonged exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.